Prefrontal lobes and memory disorder

DOI Web Site 50 References

Bibliographic Information

Other Title
  • 前頭前野と記憶障害

Search this article

Description

Prefrontal lesion is involved in working memory deficits, but not amnesic syndrome that is the disorder of episodic memory. However, recent neuropsychological researches indicated that the damages of prefrontal lobes are related to the deficits of specific aspects of encoding and retrieval of long term memory, including the disorders of temporal ordering of memory items, false recognition, and prospective memory. On working memory and prefrontal lobe function in animals, dopamine D1 receptors in the prefrontal cortex are important for working memory functions, and it is suggested that stimulation of prefrontal D1 receptors induces an inverted U-shaped response, such that too little or too much D1 receptor stimulation impairs prefrontal functions. We described a interesting positron emission tomography (PET) finding in healthy human subjects. In this study, we found an inverted U-shaped relation between prefrontal dopamine D1 receptor binding and Wisconsin Card Sorting Test performance in human.

Journal

References(50)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top