ラットのオープンフィールド行動と物体探索行動に及ぼすMK-801 の効果とその性差<SUP>1</SUP>

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  • The effect of MK-801 on openfield activities and object exploration and its sex difference
  • ラット ノ オープンフィールド コウドウ ト ブッタイ タンサク コウドウ ニ オヨボス MK-801 ノ コウカ ト ソノ セイサ

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The present study investigated the effect of MK-801 on openfield activities and object exploratory behavior in a circular openfield by using Sprague-Dawley rats. In Experiment 1, when a novel object was placed in a central zone (CZ) of the openfield, CZ-stay-time and CZ-stay-time-per-entry significantly increased, and no sex difference was shown for object exploratory behavior. In Experiment 2, MK-801 (0.05, 0.1, 0.2 mg/kg) was administered i.p.. Marked dose-dependent sex difference in object exploratory behavior and openfield activities. CZ-stay-time, CZ-stay-time-per-entry, locomotion, rearing, and leaning of males were affected by 0.1 and 0.2 mg/kg of MK-801. Females given 0.05 mg/kg of MK-801, which did not affect locomotion in males, displayed hyperactivity, and those given 0.2 mg/kg a significant reduction of activity. Females, 0.1 and 0.2 mg/kg of MK-801 affected object exploratory behavior, locomotion, rearing and leaning even on the next day of administration. These results suggested that the effect of MK-801 in female rats tends to be longer than in males, and that females are more susceptible to non-competitive NMDA receptor blockade than males.

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