Central Injection of Endomorphin-2, but not Endomorphin-1, Increases Food Intake in Chicks via .MU.1-opioid Receptors

DOI Web Site 被引用文献3件 参考文献19件 オープンアクセス
  • Bungo Takashi
    Laboratory of Animal Behavior and Physiology, Graduate School of Biosphere Science, Hiroshima University
  • Dodo Koh-Ichi
    Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University
  • Izumi Tomofumi
    Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University

書誌事項

公開日
2007
DOI
  • 10.2141/jpsa.44.205
公開者
日本家禽学会

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説明

The endogenous tetrapeptides endomorphin-1 and -2 are potent, selective μ-opioid receptor agonists in mammals. The present study was done to elucidate whether central injection of endomorphins enhances feeding behavior in chicks, and to investigate the interaction with the μ1-opioid receptor. We found that the intracerebroventricular injection of endomorphin-2 (10-30nmol) significantly stimulated food intake in neonatal chicks during the 60-min period postinjection. However, the same doses of endomorphin-1 injected with ICV had no significant effects on feeding behavior. The orexigenic effect of endomorphin-2 was significantly attenuated by the μ1-opioid receptor antagonist naloxonazine. These results indicate that the administration of endomorphin-2, but not endomorphin-1, into the chick brain produces the orexigenic effect through the μ1-opioid receptor.

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