Metabolism of the Pyrethroid Insecticide S-4068SF in Rats

SHIBA Kunio, KAKUTA Noriko, KANEKO Hideo, NAKATSUKA Iwao, YOSHITAKE Akira, YAMADA Hirohiko, MIYAMOTO Junshi

doi:10.1584/jpestics.13.557

The metabolic fate of 5-4068SF [Etoc®, (S)-2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl (1R)-trans, cis-chrysanthemate], a novel pyrethroid, was examined by administering [alcohol-¹⁴C](4S, 1R)-trans- and [alcohol-¹⁴C] (4S, 1R)-cis-S-4068 orally or subcutaneously to male and female rats at 2mg/kg. The administered radiocarbon was almost completely eliminated in urine and feces within 7 days after treatment. ¹⁴C levels in blood and other tissues reached maxima within 3hr after oral administration and thereafter decreased rapidly. Biological half-lives of ¹⁴C tissue levels for 3-12 and 12-48hr after oral administration were 3-5hr and 7-35hr, respectively. ¹⁴C tissue residues were generally very low on the 7th day after administration. Twenty metabolites found in excreta were identified. Proposed metabolic pathways of S-4068SF involved, 1) oxidation at methyl of the isobutenyl group in the acid moiety and at the C-1 or the C-2 position of the propynyl group in the alcohol moiety, 2) cleavage of ester linkage, and 3) conjugation of resultant hydroxy derivatives with glucuronic acid and sulfuric acid. There was no marked difference in the metabolic fate of (4S, 1R)-trans- or (4S, 1R)-cis-S-4068 between sexes and administration routes.

Metabolism of the Pyrethroid Insecticide S-4068SF in Rats

Bibliographic Information

Search this article

Abstract

Journal

Citations (2)*help

Keywords

Details 詳細情報について

Export

Report a problem