Quantitative Structure-Activity Relationships of the Herbicidal <i>N</i>-Benzyl-2-bromo-3, 3-dimethylbutanamides

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  • KIRINO Osamu
    Research Institute, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • FURUZAWA Kunihiko
    Research Institute, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • TAKAYAMA Chiyozo
    Research Institute, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • MATSUMOTO Hiroshi
    Research Institute, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • MINE Akihiko
    Research Institute, Pesticides Division, Sumitomo Chemical Co., Ltd.

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Other Title
  • 除草活性を有する <i>N</i>-benzyl-2-bromo-3, 3-dimethylbutanamides の定量的構造活性相関
  • 除草活性を有するN-benzyl-2-bromo-3,3-dimethylbutananamidesの定量的構造活性相関〔N-Benzylbutanamidesの除草活性-3-〕〔英文〕
  • ジョソウ カッセイ オ ユウスル N benzyl 2 bromo 3 3 d
  • Herbicidal Activity of <i>N</i>-Benzylbutanamides (Part III)

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Abstract

The growth inhibiting activity of 27 derivatives of N-benzyl-2-bromo-3, 3-dimethylbutanamide having various substituents at the α-position and the benzene ring of the N-benzyl group against bulrush, Scirpus juncoides, was determined in the vial test. The structure-activity relationships were analyzed quantitatively by physicochemical substituent parameters and multiple regression analysis. The variation in the activity of N-(α-substituted benzyl) derivatives was shown to be related parabolically with variation in the steric dimension of the substituents. The greater the hydrophobicity of substituents is, the greater the activity is. The variation in the steric dimension of the benzene ring substituents was responsible for the activity of N-(1-methyl-1-substituted phenylethyl) derivatives.

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