1-[<i>N</i>-(置換ピリジル) ベンズイミドイル] イミダゾール類の抗菌活性
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- 弓田 隆司
- K·I Chemical Research Institute Co., Ltd.
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- 吉村 巧
- K·I Chemical Research Institute Co., Ltd.
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- 平川 勝人
- Life Science Research Institute, Kumiai Chemical Industry Co., Ltd.
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- 澤井 伸光
- Life Science Research Institute, Kumiai Chemical Industry Co., Ltd.
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- 小嶋 芳幸
- Life Science Research Institute, Kumiai Chemical Industry Co., Ltd.
書誌事項
- タイトル別名
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- Fungicidal Activities of 1-[<i>N</i>-(Substituted pyridyl) benzimidoyl] imidazoles
- 1-〔N-(置換ピリジル)ベンズイミドイル〕イミダゾール類の抗菌活性〔英文〕
- 1 N チカン ピリジル ベンズイミドイル イミダゾールルイ ノ コウキン カ
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説明
We studied the acid moieties of the following imidoyl imidazole derivatives; alkyl, alkoxyl, alkoxyalkyl, substituted phenyl and aryl compounds with hetero atoms of sulfur or nitrogen in order to determine their fungicidal activities. Phenyl compounds that have ortho-substituents such as 2-trifluoromethyl were highly fungicidal. Moreover, N-substituted-2-pyridyl compounds, such as N-5-chloro-3-methyl-2-pyridyl, with amine moieties showed higher antifungal activity than N-phenyl compounds. Some of these compounds have excellent preventive, curative and systemic effects on various crop diseases. Certain N-2-pyridyl benzimidoyl imidazoles showed excellent fungicidal activity against powdery mildew and gray mold on cucumber and against blast on rice plants. 1-[N-(5-Chloro-3-methyl-2-pyridyl)-2-trifluoromethylbenzimidoyl] imidazole (48), a representative compound, had the following effects at the concentrations shown; preventive of powdery mildew at 0.54ppm and gray mold at 7.7ppm, and curative of rice blast at 16.8ppm (EC50). In addition, its antifungal spectrum was very broad, and it was especially efficacious against Basidiomycetes and Ascomycetes. At 1ppm in the nutrient medium, it strongly inhibited sporidial multiplication and ergosterol biosynthesis on Ustilago maydis. These results indicate that the mode of action of N-2-pyridyl benzimidoyl imidazoles is the inhibition of ergosterol biosynthesis.
収録刊行物
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- 日本農薬学会誌(Journal of Pesticide Science)
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日本農薬学会誌(Journal of Pesticide Science) 13 (2), 221-229, 1988
日本農薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282680185759360
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- NII論文ID
- 110001712185
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- NII書誌ID
- AN00196227
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- ISSN
- 03851559
- 13490923
- 1348589X
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- NDL書誌ID
- 3185741
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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