Manganese Stimulates Ca2+ Mobilization in Human Gingival Fibroblasts
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- Takao Masami
- Departments of Oral Diagnostics, Nihon University School of Dentistry at Matsudo
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- Nakao Sumi
- Departments of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo
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Abstract
In fura-2-loaded human gingival fibroblasts, 1-50 μM MnCl2 evoked an increase in intracellular Ca2+ concentrations ([Ca2+]i) in a dose-dependent manner. This increase was abolished in the absence of extracellular Ca2+. MnCl2 induced an increase in [Ca2+]i provoked prostaglandin E2 release in human gingival fibroblasts in time- and dose-dependent manners. MnCl2 failed to evoke prostaglandin E2 release in the absence of extracellular Ca2+. A protein kinase C activator and a tyrosine kinase inhibitor inhibited the increase in [Ca2+]i induced by MnCl2. These results suggest that Mn2+ evokes Ca2+ entry and prostaglandin E2 release in human gingival fibroblasts, which are regulated by protein kinase C and tyrosine kinase activities.
Journal
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- International Journal of Oral-Medical Sciences
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International Journal of Oral-Medical Sciences 4 (3), 148-153, 2006
Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo
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Keywords
Details 詳細情報について
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- CRID
- 1390282680185782528
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- NII Article ID
- 130000652938
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- ISSN
- 21854254
- 13479733
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed