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Manganese Stimulates Ca2+ Mobilization in Human Gingival Fibroblasts

  • Takao Masami
    Departments of Oral Diagnostics, Nihon University School of Dentistry at Matsudo
  • Nakao Sumi
    Departments of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo

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Abstract

In fura-2-loaded human gingival fibroblasts, 1-50 μM MnCl2 evoked an increase in intracellular Ca2+ concentrations ([Ca2+]i) in a dose-dependent manner. This increase was abolished in the absence of extracellular Ca2+. MnCl2 induced an increase in [Ca2+]i provoked prostaglandin E2 release in human gingival fibroblasts in time- and dose-dependent manners. MnCl2 failed to evoke prostaglandin E2 release in the absence of extracellular Ca2+. A protein kinase C activator and a tyrosine kinase inhibitor inhibited the increase in [Ca2+]i induced by MnCl2. These results suggest that Mn2+ evokes Ca2+ entry and prostaglandin E2 release in human gingival fibroblasts, which are regulated by protein kinase C and tyrosine kinase activities.

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