プロシミドンのラットおよびマウスにおける比較代謝
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- 斯波 久二雄
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 金子 秀雄
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 吉野 浩美
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 角田 紀子
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 射場 一彦
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 中塚 巌
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 吉武 彬
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 山田 宏彦
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- 宮本 純之
- Biochemistry and Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
書誌事項
- タイトル別名
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- Comparative Metabolism of Procymidone in Rats and Mice
- プロシミドンのラットおよびマウスにおける比較代謝〔英文〕
- プロシミドン ノ ラット オヨビ マウス ニ オケル ヒカク タイシャ エイブ
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抄録
The metabolic fates of procymidone [N-(3, 5-dichlorophenyl)-1, 2-dimethylcyclopropane-1, 2-dicarboximide, Sumilex®] in rats and mice were examined. After [phenyl-14C]procymidone was administered orally to male rats and mice at 100mg/kg, the radiocarbon was rapidly and almost completely excreted into excreta of both animals, mainly into the urine, within 7 days after administration. 14C-Levels in the blood of both species were fairly constant for 2-12hr, reaching maximum at 12hr in rats and at 2hr in mice after administration. The 14C-levels decreased with the biological half-lives of 12hr in rats and 10hr in mice from 8 to 72hr after administration. In both species, the major metabolic reactions were oxidation of one of the methyl groups to carboxylic acid via hydroxymethyl and cleavage of the imide linkage. No marked species differences in metabolism were observed.
収録刊行物
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- 日本農薬学会誌(Journal of Pesticide Science)
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日本農薬学会誌(Journal of Pesticide Science) 16 (1), 27-33, 1991
日本農薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282680186218496
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- NII論文ID
- 110001712445
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- NII書誌ID
- AN00196227
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- ISSN
- 03851559
- 13490923
- 1348589X
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- NDL書誌ID
- 3708427
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可