Mode of Action of Methyl <i>N</i>-(3, 5-Dichlorophenyl)-carbamate in the Benzimidazole-resistant Isolate of <i>Botrytis cinerea</i>

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  • SUZUKI Keiko
    Pesticides Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • KATO Toshiro
    Pesticides Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • TAKAHASHI Junya
    Pesticides Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • KAMOSHITA Katsuzo
    Pesticides Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.

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Other Title
  • Methyl <i>N</i>-(3, 5-dichlorophenyl) carbamate のベンズイミダゾール耐性灰色かび病菌における作用機構
  • Methyl N-(3,5-dichlorophenyl)carbamateのベンズイミダゾール耐性灰色かび病菌における作用機構〔英文〕
  • Methyl N 3,5 dichlorophenyl carbamate ノ

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Description

In the presence of 10μg/ml methyl N-(3, 5-dichlorophenyl) carbamate (MDPC), conidia of the benzimidazole-resistant isolate of Botrytis cinerea germinated but produced distorted and swollen germ tubes. Their abnormal morphology was quite similar to that of the wild-type isolate treated with methyl benzimidazol-2-yl carbamate (MBC). On the contrary, MDPC and MBC did not affect fungal morphology of the wild-type isolate and the resistant one, respectively. Furthermore, mitosis was arrested by 10 μg/ml MDPC in the resistant isolate but not in the sensitive one, whereas MBC disturbed mitosis in the wild-type isolate but not in the resistant one. Conversion of MDPC to any other products was not detected in the cultures of the resistant isolate and the wild-type one, suggesting little possibility of detoxification and activation in the organism. Moreover, the accumulation of the compound in hyphal cells occurred at a similar rate in both cultures. It is therefore unlikely that such mechanisms are operating for an increased toxicity of MDPC to the resistant strains.

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