フェンバレレート (スミサイジン<sup>®</sup>) のラットにおける代謝

DOI NDLデジタルコレクション NDLデジタルコレクション 日本農学文献記事索引 Web Site ほか1件をすべて表示 一部だけ表示 被引用文献3件 オープンアクセス
  • 大川 秀郎
    Research Department, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • 金子 秀雄
    Research Department, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • 辻 秀子
    Research Department, Pesticides Division, Sumitomo Chemical Co., Ltd.
  • 宮本 純之
    Research Department, Pesticides Division, Sumitomo Chemical Co., Ltd.

書誌事項

タイトル別名
  • Metabolism of Fenvalerate (Sumicidin<sup>®</sup>) in Rats
  • フェンバレレート(スミサイジン^[○!R])のラットにおける代謝
公開日
1979
資源種別
journal article
DOI
  • 10.1584/jpestics.4.143
公開者
日本農薬学会

この論文をさがす

説明

On either a single oral dose or 5 consecutive daily doses, the metabolism of fenvalerate [α-cyano-3-phenoxybenzyl-2-(4-chlorophenyl) isovalerate] and the (S)-acid ester isomer in male rats was rapid, and the acid moiety and the aromatic portion of the alcohol moiety were almost completely eliminated from the body within several days. The CN group of the alcohol moiety was rapidly converted mainly to thiocyanate which retained relatively longer in selective tissues including skin and hair. Fenvalerate and the (S)-acid isomer yielded two fecal ester metabolites which resulted from hydroxylation at the 4′- and 2′-phenoxy positions. Other significant metabolites were 3-phenoxybenzoic acid and its hydroxy derivatives (free and conjugates) from the alcohol-labeled compound, 3-(4-chlorophenyl) iso-valeric acid and its hydroxy derivatives (free, lactones and conjugates) from the acid-labeled compound, and thiocyanate and CO2 from the CN-labeled compounds. There were no apparent differences in the nature and amount of metabolites, and in the patterns of 14C excretion and tissue residues between fenvalerate and the (S)-acid isomer.

収録刊行物

被引用文献 (3)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ