Insecticidal Activity and Cuticular Penetration of Indoxacarb and Its <i>N</i>-Decarbomethoxylated Metabolite in Organophosphorus Insecticide-Resistant and -Susceptible Strains of the Housefly, <i>Musca domestica</i> (L.)

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  • インドキサカルブおよび脱メトキシカルボニル代謝物の有機リン剤抵抗性および感受性イエバエに対する殺虫活性と皮膚透過性
  • Insecticidal Activity and Cuticular Penetration of Indoxacarb and Its N-Decarbomethoxylated Metabolite in Organophosphorus Insecticide-Resistant and -Susceptible Strains of the Housefly, Musca domestica (L.)

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Abstract

Indoxacarb, the novel oxadiazine insecticide showed potent insecticidal activities in insecticide-susceptible (SRS) and organophosphorus insecticide-resistant (R-OP) strains of the housefly, Musca domestica (L.). The R-OP strain showed slightly less susceptibility to indoxacarb with the tolerance ratio of 2.5. N-Decarbomethoxylated metabolite of indoxacarb (DCJW) also showed insecticidal activity that was more potent than indoxacarb in both SRS and R-OP strains. Similar to indoxacarb, the R-OP strain showed less susceptibility to DCJW with the tolerance ratio of 6.1. Cuticular penetration experiments revealed that the R-OP strain showed more external persistency and less internal accumulation of indoxacarb and DCJW than the susceptible strain. The reduced cuticular penetration could account for the less susceptibility of the R-OP strain to indoxacarb and DCJW. Further analyses revealed that DCJW was excreted more slowly than indoxacarb which could be one of the factors of differences in insecticidal activity between the two chemicals.

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