2-(アリールイミノ) オキサゾリジン, 2-(置換ベンジルアミノ)-2-オキサゾリン類の合成とオクトパミンアゴニスト活性
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- 平島 明法
- Department of Agricultural Chemistry, Kyushu University
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- 潘 燦平
- Department of Agricultural Chemistry, Kyushu University
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- 片渕 裕美子
- Department of Agricultural Chemistry, Kyushu University
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- 谷口 栄二
- Department of Agricultural Chemistry, Kyushu University
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- 江藤 守総
- Department of Agricultural Chemistry, Kyushu University Miyakonojo National College of Technology
書誌事項
- タイトル別名
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- Synthesis and Octopaminergic-Agonist Activity of 2-(Arylimino)oxazolidines and 2-(Substituted Benzylamino)-2-oxazolines
- Synthesis and Octopaminergic-Agonist Activity of 2-(Arylimino)oxazolidines and 2-(Substituted Bezylamino)-2-oxazolidines
- Synthesis and Octopaminergic-Agonist Ac
この論文をさがす
説明
2-(Arylimino)oxazolidines (AIOs) and 2-(substituted benzylamino)-2-oxazolines (SBOs) were obtained by cyclodesulfurizing the corresponding thiourea with yellow mercuric oxide. The activity for stimulating adenylate cyclase prepared from thoracic nerve cords of the American cockroach Periplaneta americana L. was examined by these compounds. Greater enzyme activation appeared to result from alkyl substitution at the 2, 6-positions or 2-alkyl 4-halogen at the phenyl ring of AIOs. A halogen in the m- and/or p-position, or methyl group at p-position seems to be a favorable substituent on the phenyl ring of SBO compounds for octopaminergic-agonist activity. SBO with a 3, 4-dichlorophenyl group (36) was less active than its thiazoline derivative, 2-(3, 4-dichlorophenylamino)-2-thiazoline (CBT) in terms of Ka and Vmax: Ka and Vmax of 36 were 2.3μM and 29% relative to OA, whereas those of CBT have been 0.40μM and 53% relative to OA, respectively. Superimposition of energy-minimized OA and CBT revealed structural and conformational similarities that might account for the high activity of CBT.
収録刊行物
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- 日本農薬学会誌(Journal of Pesticide Science)
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日本農薬学会誌(Journal of Pesticide Science) 21 (4), 419-424, 1996
日本農薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282680187538944
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- NII論文ID
- 110001712949
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- NII書誌ID
- AN00196227
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- ISSN
- 03851559
- 13490923
- 1348589X
- http://id.crossref.org/issn/1348589X
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- NDL書誌ID
- 4078560
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可