Fate and Metabolism of Radiolabelled Insecticide Azinphos-methyl in Rat

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  • [メトキシ-<sup>14</sup>C] アジンホスメチルのラットにおける動態および代謝
  • Fate and Metabolism of Radiolabelled In

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The metabolism of [methoxy-14C] Azinphos-methyl in the rat, following administration of a single oral dose, was investigated. The major part of 14C-activity was eliminated in the expired air within 48hr as 14CO2. After that time the organs of the rat did not contain any appreciable radioactive residues. Seven radiolabelled, in addition to six non-labelled, metabolites have been detected in the urine. Of these two labelled and non-labelled could not be completely identified and are still under further investigation. Most of the identified metabolites are formed via cleavage of P-O methyl ester bond.

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