Partition of 2, 4-Dichiorophenoxyacetic Acid Derivatives in Phosphatidyicholine Multi-lamellar Vesicles

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  • 2,4-D誘導体のホスファチジルコリン多重層リポソームへの分配
  • Partition of 2,4-Dichlorophenoxyacetic Acid Derivatives in Phosphatidylcholine Multi-lamellar Vesicles

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Abstract

The interaction of 2, 4-dichlorophenoxyacetic acid (2, 4-D) with multi-lamellar vesicles of dimyristoyl and dipalmitoyl L-α-phosphatidylcholine was examined from the pH dependency of partition and pH-and temperature-dependent polarization of fluorescence probes such as 1, 6-Biphenyl-1, 3, 5-hexatriene. It was strongly suggested that 2, 4-D in the undissociated form was located at the region from the neighborhood of the glycerol backbone to a shallow site of the hydrophobic core of the lipid bilayers and that its anionic species was adsorbed at the membrane surface. Fluorescence study with the derivatives of 2, 4-D showed that hydrophobicity and pKa of these acids determined their interaction with membrane.

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