Mode of action of novel acaricide pyflubumide: Effects on the mitochondrial respiratory chain
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- Nakano Motofumi
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- Yasokawa Noriaki
- Development Department, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- Suwa Akiyuki
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- Fujioka Shinsuke
- Development Department, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- Furuya Takashi
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- Sakata Kazuyuki
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
Bibliographic Information
- Other Title
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- 新規殺ダニ剤ピフルブミドの作用機構:ミトコンドリア呼吸鎖に対する影響
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Abstract
This study aimed to determine the mode of action of pyflubumide, a novel acaricide under development by Nihon Nohyaku Co., Ltd. Because of its structural similarity to succinate-dehydrogenase inhibitor (SDHI) fungicides, its ability to inhibit mitochondrial complex II was investigated. Pyflubumide exhibited low inhibitory activity on spider mite mitochondria; conversely, its deacylated metabolite (NH-form) showed high mitochondrial inhibitory activity. Pyflubumide was quickly metabolized to its NH-form in the homogenate of spider mites. These results suggest that pyflubumide is a prodrug and that the NH-form is active. Indeed, the NH-form of pyflubumide and the OH-form of cyenopyrafen, a complex II inhibitory acaricide, act on the same enzyme; a double-inhibitor titration assay showed that the binding sites on mitochondrial complex II and/or the manners of binding of these compounds exhibit clear differences. This finding suggests that these two acaricides should be classified into different groups in terms of their mode of action.
Journal
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- Journal of Pesticide Science
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Journal of Pesticide Science 40 (1), 19-24, 2015
Pesticide Science Society of Japan
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Details 詳細情報について
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- CRID
- 1390282680188339968
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- NII Article ID
- 130004939750
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- NII Book ID
- AA11818622
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- ISSN
- 13490923
- 03851559
- 1348589X
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- NDL BIB ID
- 026393036
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed