<b>ImagingModalitiesinPredictingTumorRecurrenceofOralSquamousCellCarcinoma </b><b>(OSCC): Earlier Detection, Better Relief </b>

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  • Zarin Zainul
    Center for Cell-Matrix Research and Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, P. O. Box 5000, 90014 University of Oulu, Finland

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  • ImagingModalitiesinPredictingTumorRecurrenceofOralSquamousCellCarcinoma (OSCC): Earlier Detection, Better Relief

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Abstract

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. However, combinations of more aggressive treatments have been unable to substantially improve the 5-year survival rate, due to a 10-30% locoregional recurrence rate. Conventional approaches such as physical examination, magnetic resonance imaging (MRI) and computed tomography (CT) are generally presumed insufficient for detecting residual or recurrent tumors during follow-up. Posttreatment prediction of tumor recurrence remains a diagnostic challenge. This article reviews the utilization of various non-invasive imaging modalities, such as 18F-fluorodeoxyglucose-positron emission tomography (PET), PET/ CT, MRI, dynamic contrast-enhanced-MRI, diffusion-weighted MRI, CT, perfusion-CT and ultrasonography in addition to physical examination for earlier prediction of tumor recurrence in patients with OSCC during follow-up. A need for high-level scientific evidence remains, to guide us to the optimal radiological strategies for earlier prediction of tumor recurrence in OSCC. Further investigation is thus needed to standardize these methods for predicting tumor recurrence.

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