Hydroquinone, a Benzene Metabolite, Induces Hog1-dependent Stress Response Signaling and Causes Aneuploidy in Saccharomyces cerevisiae
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- SHIGA Takeki
- Graduate School of Life Sciences, Tohoku University
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- SUZUKI Hiroyuki
- Graduate School of Life Sciences, Tohoku University
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- YAMAMOTO Ayumi
- Department of Chemical and Biological Engineering, Hachinohe National College of Technology
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- YAMAMOTO Hiroaki
- Graduate School of Life Sciences, Tohoku University Nagahama Institute of Bio-Science and Technology
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- YAMAMOTO Kazuo
- Graduate School of Life Sciences, Tohoku University
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Previously, we have shown that phenyl hydroquinone, a hepatic metabolite of the Ames test-negative carcinogen o-phenylphenol, efficiently induced aneuploidy in Saccharomyces cerevisiae by arresting the cell cycle at the G2/M transition as a result of the activation of the Hog1 (p38 MAPK homolog)-Swe1 (Wee1 homolog) pathway. In this experiment, we examined the aneuploidy forming effects of hydroquinone, a benzene metabolite, since both phenyl hydroquinone and hydroquinone are Ames-test negative carcinogens and share similar molecular structures. As was seen in phenyl hydroquinone, hydroquinone induced aneuploidy in yeast by delaying the cell cycle at the G2/M transition. Deficiencies in SWE1 and HOG1 abolished the hydroquinone-induced delay at the G2/M transition and aneuploidy formation. Furthermore, Hog1 was phosphorylated by hydroquinone, which may stabilize Swe1. These data indicate that the hydroquinone-induced G2/M transition checkpoint, which is activated by the Hog1-Swe1 pathway, plays a role in the formation of aneuploidy.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 51 (4), 405-415, 2010
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680192262912
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- NII論文ID
- 10026563857
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 10766053
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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