Protective Effect of Prostaglandin E₁ on Radiation-Induced Proliferative Inhibition and Apoptosis in Keratinocytes and Healing of Radiation-Induced Skin Injury in Rats

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  • TAKIKAWA Megumi
    Department of Plastic Surgery, National Defense Medical College
  • SUMI Yuki
    Department of Plastic Surgery, National Defense Medical College
  • TANAKA Yoshihiro
    Division of Biomedical Engineering, Research Institute, National Defense Medical College
  • NAMBU Masaki
    Department of Plastic Surgery, National Defense Medical College
  • DOUMOTO Takashi
    Department of Plastic Surgery, National Defense Medical College
  • YANAGIBAYASHI Satoshi
    Department of Plastic Surgery, National Defense Medical College
  • AZUMA Ryuichi
    Department of Plastic Surgery, National Defense Medical College
  • YAMAMOTO Naoto
    Department of Plastic Surgery, National Defense Medical College
  • KISHIMOTO Satoko
    Division of Biomedical Engineering, Research Institute, National Defense Medical College Reseach Fellow of the Japan Society for Promotion of Science
  • ISHIHARA Masayuki
    Division of Biomedical Engineering, Research Institute, National Defense Medical College
  • KIYOSAWA Tomoharu
    Department of Plastic Surgery, National Defense Medical College

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タイトル別名
  • Protective Effect of Prostaglandin E<sub>1</sub> on Radiation-Induced Proliferative Inhibition and Apoptosis in Keratinocytes and Healing of Radiation-Induced Skin Injury in Rats

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We examined the effects of prostaglandin E1 (PGE1) on radiation-induced proliferation inhibition and apoptosis in keratinocytes and healing of radiation-induced skin injury in a rat model. PGE1 had a protective effect on radiation-induced growth inhibition in keratinocytes in vitro, but not in fibroblasts. Varying concentrations of PGE1 were subcutaneously administered into the posterior neck region. X-irradiation at a dose of 20 Gy was administrated to the lower part of the back using a lead sheet with two holes 30 min to 1 h before or after the administration of PGE1. Although X-irradiation induced epilation, minor erosions, or skin ulcers in almost all rats, PGE1 administration prior to irradiation reduced these irradiation injuries. Staining with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling showed that proportions of apoptotic keratinocytes in the X-irradiated skin of PGE1-administered rats were significantly lower than for those in the skin of rats which did not receive PGE1. Cutaneous full-thickness defective wounds were then formed in X-irradiated areas to examine the time course of wound healing. Wound healing was significantly delayed because of X-irradiation, but PGE1 administration prior to irradiation led to a significantly shorter delay in wound healing compared with controls. Decreasing delay in wound healing was correlated with concentration of PGE1 administrated. Thus, PGE1-administration may potentially alleviate the radiation-induced skin injury.

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