Pericardial and Pleural Effusions after Definitive Radiotherapy for Esophageal Cancer
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- FUKADA Junichi
- Department of Radiology, Keio University, School of Medicine
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- SHIGEMATSU Naoyuki
- Department of Radiology, Keio University, School of Medicine
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- OHASHI Toshio
- Department of Radiology, Keio University, School of Medicine
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- SHIRAISHI Yutaka
- Department of Radiology, Keio University, School of Medicine
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- TAKEUCHI Hiroya
- Department of Surgery, Keio University, School of Medicine
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- KAWAGUCHI Osamu
- Department of Radiology, Keio University, School of Medicine
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- KITAGAWA Yuko
- Department of Surgery, Keio University, School of Medicine
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Purpose: We investigated the incidences of pericardial and pleural effusions after definitive radiotherapy with or without concurrent chemotherapy were analyzed retrospectively. Methods: One hundred and forty-seven patients with esophageal cancer received definitive radiotherapy or concurrent chemoradiotherapy (CCR). Follow-up chest Computed Tomography scans were reviewed to detect pericardial and pleural effusions. Adverse events were graded according to the Radiation Therapy Oncology Group Common Toxicity Criteria. Results: The median follow-up was 34 (range, 6 to 84) months. Numbers of eligible patients evaluated for pericardial and pleural effusions were 107 and 101, respectively. Pericardial effusions exceeding grade 1 and grade 2 toxicities were observed in 46 (43%) and 15 (14%) patients, respectively. The corresponding numbers for pleural effusions were 44 (44%) and 18 (18%). Onset of effusion ranged from 1 to 65 months after treatment. Multivariate analysis identified radiation field width of the mediastinum exceeding 8 cm as a significant risk factor for both pericardial and pleural effusions. Age and field length exceeding 20 cm were identified as independent risk factors for pleural effusion. Conclusions: Pericardial and pleural effusions after radiotherapy or CCR are occasionally recognized as adverse events in patients with esophageal cancer. The mediastinal radiation field width can be a simple indicator for predicting those adverse events.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 53 (3), 447-453, 2012
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680192553472
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- NII論文ID
- 130001876860
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:DC%2BC38jltlOruw%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 023682832
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- PubMed
- 22739014
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可