Predictive Value of 18F-Fluorodeoxyglucose Uptake by Positron Emission Tomography for Non-Small Cell Lung Cancer Patients Treated with Radical Radiotherapy

DOI PDF Web Site 参考文献55件
  • IKUSHIMA Hitoshi
    Departments of Radiation Physics, The University of Texas M. D. Anderson Cancer Center
  • DONG Lei
    Departments of Radiation Physics, The University of Texas M. D. Anderson Cancer Center
  • ERASMUS Jeremy
    Departments of Radiology, The University of Texas M. D. Anderson Cancer Center
  • ALLEN Pamela
    Departments of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center
  • MCALEER Mary F.
    Departments of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center
  • ZHUANG Yan
    Departments of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center
  • SASAKI Ryohei
    Department of Radiology, The University of Kobe
  • KOMAKI Ritsuko
    Departments of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center

この論文をさがす

抄録

The purpose of this study is to assess predictive value of the positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) for recurrence and survival after radiotherapy (RT) for non-small cell lung cancer (NSCLC). One hundred forty-nine patients underwent pretreatment PET (n = 67) or PET/computed tomography (CT) (n = 82) and definitive RT for NSCLC. We evaluated the relationship between the maximum-pixel standardized uptake value (SUVmax) and clinical tumor features. Univariate Cox proportional hazard analysis (UVA) was used to quantify the risk for local-regional recurrence, distant metastases, and death. Multivariate Cox proportional hazard analysis (MVA) was used to assess the potential independent effect of SUVmax. In the PET group, T1 tumors showed significantly lower SUVmax than T2, T3, and T4 tumors; in the PET/CT group, T1 tumors showed significantly lower SUVmax than T3 and T4 tumors. A high SUVmax was a negative factor for local-regional control (LRC) (p < 0.001), distant metastasis-free survival (DMFS) (p = 0.02), and overall survival (OS) (p = 0.001) on UVA in the PET group. However, the significance decreased to 0.05 for LRC, 0.04 for DMFS, and 0.04 for OS by MVA when tumor size was included in the analysis. A high SUVmax was not a negative factor for LRC, DMFS, or OS on UVA and MVA in the PET/CT group. In conclusion, assessment of predictive value of SUVmax for NSCLC requires consideration of primary tumor size, and the evidence is not sufficient to suggest that FDG uptake in a primary NSCLC provides prognostic information.

収録刊行物

参考文献 (55)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ