Differences in heavy-ion-induced DNA double-strand breaks in a mouse DNA repair-deficient mutant cell line (SL3-147) before and after chromatin proteolysis.

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  • MURAKAMI MASAHIRO
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences
  • EGUCHI-KASAI KIYOMI
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences
  • SATO KOKI
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences
  • MINOHARA SHINICHI
    Division of Accelerator Physics and Engineering, National Institute of Radiological Sciences
  • YATAGAI FUMIO
    Institute of Physical and Chemical Research
  • KANAI TATSUAKI
    Division of Accelerator Physics and Engineering, National Institute of Radiological Sciences

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DNA double-strand breaks induced by X- or neon beam-irradiation in a DNA double-strand break-repair-deficient mutant cell line (SL3-147) were examined. The increase in the number of DNA double-strand breaks was dose depend after irradiation with X-rays and neon beams and was enhanced by chromatin-proteolysis treatment before irradiation. These results suggest that the induction of DNA double-strand breaks by ionizing radiation, including heavy-ions, is influenced by the chromatin structure.

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