Dose-response Relationship for Induction of Solid Tumors in Female B6C3F1 Mice Irradiated Neonatally with a Single Dose of Gamma Rays

DOI NDLデジタルコレクション NDLデジタルコレクション PDF Web Site ほか2件をすべて表示 一部だけ表示 被引用文献9件 参考文献39件
  • SASAKI SHUNSAKU
    Research Group of Low-Dose Radiation Effects and Carcinogenesis, National Institute of Radiological Sciences
  • FUKUDA NOBUO
    Research Group of Low-Dose Radiation Effects and Carcinogenesis, National Institute of Radiological Sciences

書誌事項

タイトル別名
  • Dose-response Relationship for Induction of Solid Tumors in Female B6C3F<sub>1</sub> Mice Irradiated Neonatally with a Single Dose of Gamma Rays
  • Dose-response Relationship for Induction of Solid Tumors in Female B6C3F_1 ice Irradiated Neonatally with a Single Dose of Gamma Rays
公開日
1999
資源種別
journal article
DOI
  • 10.1269/jrr.40.229
公開者
Journal of Radiation Research 編集委員会

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説明

Our previous studies showed that mice during infancy are highly susceptible to the induction of several types of solid tumors. The present study was designed to elucidate the dose-response relationships for induction of solid tumors after exposure to 0.48-5.70 Gy of 137Cs gamma rays in the neonatal period in female mice. A total of 2988 mice were allowed to live out their life span under a specific pathogen free condition and lifetime incidences of liver, pituitary, ovarian, lung and bone tumors were recorded. The dose-response curves for liver, pituitary, ovarian and lung tumors were convex upward in the dose range examined, and were composed of three parts: an initial rapid increase of incidence at doses below 1 Gy, a gradual increase to the highest incidence, and a decrease in incidence with increasing dose in the higher dose range. The dose which induces neoplasm at the highest incidence seemed to be different for each type of solid tumor. The shape of the dose-response curve for induction of bone tumors was quite different from that for other solid tumors; the initial slope of the curve was concave upward. Dose-response relationships were analyzed using a model that allows for tumorigenic effect, inactivation of potentially tumorigenic cells and competing risks. The results showed that the tumorigenic effect was proportional to the dose of gamma rays for induction of liver, pituitary, ovarian and lung tumors; whereas the tumorigenic effect for bone tumors was proportional to the square of the dose. A significant increase in incidence was also found for gastrointestinal tumors, kidney tumors, adrenal tumors and hemangiomas of spleen, although dose-response relationships could not be analyzed.

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