Tumor Induction by Monoenergetic Neutrons in B6C3F1 mice

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  • WATANABE Hiromitsu
    Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • KASHIMOTO Naoki
    Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • KAJIMURA Junko
    Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • ISHIKAWA Masayori
    Department of Medical Physics, Hokkaido University
  • KAMIYA Kenji
    Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University

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Abstract

This study was undertaken to investigate induction of tumors by monoenergetic neutrons in B6C3F1 mice. Individual groups of 6 week-old animals of both sexes (about 30 mice/group) were exposed to 0.5 Gy of various monoenergetic neutrons (dose rate 0.5 cGy/min) and then observed for 13 months. The incidences of tumors (mainly liver neoplasms) in non-irradiated male and female controls were 11% and 0%, respectively. In the irradiated animals, the incidences were 53%, 50%, 60% and 43% in males, and 75%, 81%, 71%, and 85% in females, after 0.18, 0.32, 0.6 and 1.0 MeV neutron exposure, respectively. There were no significant differences in the tumor induction rate among the different energy groups.<br>

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