Radiobiological Effectiveness of Laser Accelerated Electrons in Comparison to Electron Beams from a Conventional Linear Accelerator

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  • LASCHINSKY Lydia
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
  • BAUMANN Michael
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
  • BEYREUTHER Elke
    Helmholtz-Zentrum Dresden-Rossendorf
  • ENGHARDT Wolfgang
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität Helmholtz-Zentrum Dresden-Rossendorf
  • KALUZA Malte
    Institute of Optics and Quantum Electronics, Friedrich-Schiller-University
  • KARSCH Leonhard
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
  • LESSMANN Elisabeth
    Helmholtz-Zentrum Dresden-Rossendorf
  • NAUMBURGER Doreen
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
  • NICOLAI Maria
    Institute of Optics and Quantum Electronics, Friedrich-Schiller-University
  • RICHTER Christian
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität Helmholtz-Zentrum Dresden-Rossendorf
  • SAUERBREY Roland
    Helmholtz-Zentrum Dresden-Rossendorf
  • SCHLENVOIGT Hans-Peter
    Institute of Optics and Quantum Electronics, Friedrich-Schiller-University
  • PAWELKE Jörg
    OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität Helmholtz-Zentrum Dresden-Rossendorf

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The notable progress in laser particle acceleration technology promises potential medical application in cancer therapy through compact and cost effective laser devices that are suitable for already existing clinics. Previously, consequences on the radiobiological response by laser driven particle beams characterised by an ultra high peak dose rate have to be investigated. Therefore, tumour and non-malignant cells were irradiated with pulsed laser accelerated electrons at the JETI facility for the comparison with continuous electrons of a conventional therapy LINAC. Dose response curves were measured for the biological endpoints clonogenic survival and residual DNA double strand breaks. The overall results show no significant differences in radiobiological response for in vitro cell experiments between laser accelerated pulsed and clinical used electron beams. These first systematic in vitro cell response studies with precise dosimetry to laser driven electron beams represent a first step toward the long term aim of the application of laser accelerated particles in radiotherapy.

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