Comparison of Implant Quality between Loose and Intra-operatively Linked lodine-125 Seeds in Prostate Cancer Brachytherapy
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- JARUSEVICIUS Laimonas
- Lithuanian University of Health Sciences, Oncology institute Eiveniu 2
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- INCIURA Arturas
- Lithuanian University of Health Sciences, Oncology institute Eiveniu 2
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- JUOZAITYTE Elona
- Lithuanian University of Health Sciences, Oncology institute Eiveniu 2
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- VAICIUNAS Kestutis
- Lithuanian University of Health Sciences, Department of Urology Eiveniu 2
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- VAITKUS Antanas
- Lithuanian University of Health Sciences, Oncology institute Eiveniu 2
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- SNIUREVICIUTE Migle
- Lithuanian University of Health Sciences, Oncology institute Eiveniu 2
書誌事項
- タイトル別名
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- Comparison of Implant Quality between Loose and Intra-operatively Linked Iodine-125 Seeds in Prostate Cancer Brachytherapy
この論文をさがす
抄録
From 2007 to 2010, 230 patients had iodine-125 seeds implanted (loose or intra-operatively linked into seed trains with variable seed-to-seed spacing). The primary aim was to evaluate differences in implant quality by comparing the intra-operative and post-implant dosimetry in patients treated with loose and intra-operatively linked seeds. The secondary aim was to evaluate the "learning curve" for the procedure. The following parameters were compared: the radiation dose to 90% of the prostate volume (D90), the radiation dose to 30% of the urethral volume (DU30), the percentage of the prostate volume receiving 100% or 200% of the prescribed dose (V100 or V200, respectively), the percentage of the rectal volume receiving 100% of the prescribed dose (VR100), and the homogeneity index (HI). We obtained the following results for loose vs. intra-operatively linked seeds: D90 (Gy), 184.7 ± 15.0 vs. 177.9 ± 12.7 (p = 0.002); V100 (%), 95.5 ± 2.4 vs. 94.9 ± 3.2 (p = 0.206); V200 (%), 35.1 ± 7.5 vs. 24.3 ± 6,9 (p < 0.001); DU30 (Gy), 218.6 ± 24.1 vs. 197.4 ± 19.5 (p = 0.001); VR100 (cm3), 0.6 ± 0.47 vs. 0.3 ± 0.3 (p < 0.001); HI (%), 31.8 ± 7.3 vs. 44.0 ± 9.8 (p < 0.001). The advantages of intra-operatively linked seed implantation over loose seed implantation are a more homogeneous prostate dose and lower urethral and rectal doses. The disadvantage is a lower post-implant D90. Sufficient experience with the loose seed implantation procedure was obtained after the first 40 patients. There was essentially no learning curve when a new implantation method using intra-operatively linked seeds was subsequently initiated.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 53 (3), 439-446, 2012
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680193900288
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- NII論文ID
- 130001876845
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:DC%2BC38jltlOrug%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 023682821
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- PubMed
- 22739013
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可