Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer
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- TESHIMA Keiko
- Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University
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- MURAKAMI Ryuji
- Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University
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- YOSHIDA Ryoji
- Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University
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- NAKAYAMA Hideki
- Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University
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- HIRAKI Akimitsu
- Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University
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- HIRAI Toshinori
- Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University
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- NAKAGUCHI Yuji
- Department of Radiological Technology, Kumamoto University Hospital
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- TSUJITA Naoko
- Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University
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- TOMITAKA Etsushi
- Department of Radiology, National Hospital Organization Kumamoto Medical Center
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- FURUSAWA Mitsuhiro
- Department of Radiology, Kumamoto City Hospital
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- YAMASHITA Yasuyuki
- Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University
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- SHINOHARA Masanori
- Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University
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Abstract
We retrospectively evaluated the relationship between computed tomography (CT)- and histopathological findings of parotid and submandibular glands in six patients treated for advanced oral cancer. Eligibility criteria were a pathologic diagnosis of oral squamous cell carcinoma, preoperative chemoradiation therapy (CRT) with a total dose of 30 Gy and oral S-1 (80 mg/m2/day), the availability of morphological assessments by CT and of functional assessments with the Saxon test before- and 2 weeks after CRT, and the availability of histopathological slides of irradiated parotid and submandibular glands. In the histopathological interpretation, gland structures were divided into acinar-, duct-, and adipose cells and other tissues. The Mann-Whitney test and the Spearman rank correlation test were used to determine histopathological changes. After 30-Gy irradiation, saliva production and parotid and submandibular volumes were significantly decreased (P < 0.05 each). Histopathological analysis demonstrated that 30-Gy irradiation resulted in a loss of acinar cells although acinar cells in the submandibular gland were relatively retained; the median acinar rate in the parotid and submandibular glands was 1.1% and 19.0%, respectively. The CT values after CRT were inversely correlated with adipose ratios (r = –0.98, P < 0.01) and there was a strong correlation between CT values before and after CRT (r = 0.97, P < 0.01). Our results suggested that acinar cell loss is a main contributor to changes in the volume and function of irradiated human parotid and submandibular glands. The CT value may reflect the adipose ratio rather than salivary function.
Journal
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- Journal of Radiation Research
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Journal of Radiation Research 53 (3), 492-496, 2012
Journal of Radiation Research Editorial Committee
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Details 詳細情報について
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- CRID
- 1390282680193909760
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- NII Article ID
- 130001876862
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- NII Book ID
- AA00705792
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- COI
- 1:STN:280:DC%2BC38rjt1WrtA%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL BIB ID
- 023682953
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- PubMed
- 22485019
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed