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- WU Shao-Jie
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- WANG Yu-Jue
- Department of Laboratory Animal Center, Southern Medical University
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- GUO Kun-Yuan
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- CHEN Chi
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- ZHAO Tong-Feng
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- SUN Mao-Ben
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- GU Wei-Wang
- Department of Laboratory Animal Center, Southern Medical University
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- GAO Ying Ying
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- HAN Hui Juan
- Department of Hemotology, Zhujiang Hospital, Southern Medical University
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- ZOU Fei
- School of Public Health and Tropical Medicine, Southern Medical University
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抄録
The purpose of this study was to determine the time-dose-effect of total body X-ray irradiation on lymphocytes in lymph nodes and peripheral blood in Tibet minipigs. Forty-eight Tibet minipigs were assigned into 6 groups including 5 experimental groups with 9 and the control group with 3. The minipigs in experimental groups were subjected to a total body X-ray irradiation of 2, 5, 8, 11, and 14 Gy respectively. Lymph nodes and peripheral blood samples were collected at 6, 24, and 72 hours after X-ray exposure and received histological microscopy examination and apoptosis analysis. Histology observation showed that the number of lymphocytes decreased within the lymph nodes with the increase of radiation doses and exposure time. The observation of transmission electron microscopy (TEM) showed typical apoptotic cells below 11 Gy while at 14 Gy necrotic cells were dominant. The apoptotic rate of lymphocytes in the lymph nodes was positively correlated with radiation dose in the range of 2–11 Gy, and reached the maximal level (39.4 ± 2.8) at 24 hours after 11 Gy irradiation, followed by a decrease in the apoptotic rate, but still higher than that of the control group. The number of lymphocytes in the peripheral blood samples was decreased significantly by increasing of the radiation dose and exposure time. We conclude that early damage of lymphocytes by total body X-ray irradiation is dose and time dependent below 11 Gy and before 24 hours post irradiation, and that the dosage of irradiation less than 11 Gy induced apoptosis, whereas the dose at 14 Gy resulted in necrosis in lymphocytes of the lymph nodes.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 53 (1), 18-23, 2012
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680194049024
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- NII論文ID
- 10030023346
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 023407679
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可