Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions

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  • KAWATA TETSUYA
    Department of Radiology, Graduate School of Medicine, Chiba University
  • ITO HISAO
    Department of Radiology, Graduate School of Medicine, Chiba University
  • MOTOORI KEN
    Department of Radiology, Graduate School of Medicine, Chiba University
  • UEDA TAKUYA
    Department of Radiology, Graduate School of Medicine, Chiba University
  • SHIGEMATSU NAOYUKI
    Department of Radiology, School of Medicine, Keio University
  • FURUSAWA YOSHIYA
    Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences
  • DURANTE MARCO
    Dipartimento. di Scinze Fisiche, Università "Federico II"
  • GEORGE KERRY
    NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory
  • WU HONGLU
    NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory
  • CUCINOTTA FRANCIS A.
    NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory
  • Cucinotta F A
    NASA JSC

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Abstract

The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to γ-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.<br>

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