Effects of the Restriction of Food and Water Intake on the Distribution and Retention of Radioiodine in Mice
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- TAKAHASHI SENTARO
- The 4th Research Group, National Institute of Radiological Sciences
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- THUY DAO THI BICH
- Research Fellow of Science and Technology Agency
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- SATO HIROSHI
- The 4th Research Group, National Institute of Radiological Sciences
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- KUBOTA YOSHIHISA
- The 4th Research Group, National Institute of Radiological Sciences
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- SUN XUE-ZHI
- The 4th Research Group, National Institute of Radiological Sciences
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- CHANDRASEKHARAN N. V.
- Research Fellow of Science and Technology Agency
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The effects of the restriction of food and water intakes on gastrointestinal absorption, distribution to organs and excretion of 131I were investigated in C3H/He mice. The animals were divided into four groups and administered orally 37 kBq carrier-free Na131I in 0.25 ml normal saline. One group of animals was given food and water ad libitum throughout the experimental period. Food and water to the remaining groups were restricted before and/or after the administration of 131I. The animals in each group were sacrificed 4 h and 24 h after administration, and the activity of 131I in thyroid, blood, liver, kidney, gastrointestinal tract, urine, feces, and carcass was measured. There was a significant increase in the retention of 131I in the thyroid and the concentration of 131I in the blood due to the restriction of food and water after the administration of 131I. In contrast, a significant decrease in the urinary excretion was observed in these animals. In those animals, which fasted before administration only, the retention of 131I in the thyroid and other organs were decreased. Therefore, for an accurate diagnosis and effective therapy with radioiodine as well as effective radiation protection, the intake of food and water should be taken into account.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 41 (3), 313-320, 2000
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680194324608
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- NII論文ID
- 110002328726
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:DC%2BD3M3isVCmtQ%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 5564169
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- PubMed
- 11210832
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可