Medium-mediated Bystander Effects on HSG Cells Co-cultivated with Cells lrradiated by X-rays or a 290 MeV/u Carbon Beam.
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- SHAO CHUNLIN
- Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences
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- AOKI MIZUHO
- Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences
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- FURUSAWA YOSHIYA
- Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences
Bibliographic Information
- Other Title
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- Medium-mediated Bystander Effects on HSG Cells Co-cultivated with Cells Irradiated by X-rays or a 290 MeV/u Carbon Beam
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Abstract
The mechanisms of medium-mediated bystander effects on cell survival and micronucleus (MN) induction were investigated by co-cultivating unirradiated HSG cells with cells irradiated by X-rays or 290 MeV/u carbon beams. It was found that the survival of the irradiated cells exponentially decreased along with the dose, and that the plating efficiency (PE) of the unirradiated recipient cells was obviously more enhanced than that of the control cells. Moreover, MN was induced in the unirradiated recipient cells and its yield had a maximum distribution corresponding to the donor dose, which was different from the linear-quadratic dose response of the yield of MN in the irradiated cells. The treatment of PTIO, a scavenger of nitric oxide (NO), decreased both PE and MN of the unirradiated recipient cells to control levels. Moreover, nitrite was detected in the co-culture medium, and its concentration was related to the donor dose. These results indicated that NO was involved in the above mentioned medium-mediated bystander effects. In addition, an equation was deduced to well fit the induction of MN of the unirradiated recipient cells.
Journal
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- Journal of Radiation Research
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Journal of Radiation Research 42 (3), 305-316, 2001
Journal of Radiation Research Editorial Committee
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Details 詳細情報について
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- CRID
- 1390282680194331520
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- NII Article ID
- 110002328759
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- NII Book ID
- AA00705792
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- COI
- 1:CAS:528:DC%2BD38XosVM%3D
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- ISSN
- 13499157
- 04493060
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- NDL BIB ID
- 5995616
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- PubMed
- 11840647
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed