Protective Effect of Triphlorethol-A from Ecklonia cava against Ionizing Radiation in vitro

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  • KANG Kyoung Ah
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
  • ZHANG Rui
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
  • LEE Kyoung Hwa
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
  • CHAE Sungwook
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
  • KIM Bum Joon
    Department of Microbiology and Cancer Research Institute, Seoul National University
  • KWAK Young Sook
    Department of Psychiatry, College of Medicine, Cheju National University
  • PARK Jae Woo
    Department of Nuclear and Energy Engineering, Cheju National University
  • LEE Nam Ho
    Department of Chemistry, College of Natural Sciences, Cheju National University
  • HYUN Jin Won
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University

書誌事項

公開日
2006
DOI
  • 10.1269/jrr.47.61
公開者
Journal of Radiation Research 編集委員会

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説明

We studied the cytoprotective effect of triphlorethol-A against γ-ray radiation- induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by γ-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS.<br>

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