Effect of Tinospora Cordifolia on Gamma ray-induced Perturbations in Macrophages and Splenocytes

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  • SINGH Lakshman
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences
  • TYAGI Sonia
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences
  • RIZVI Moshahid Alam
    Department of Biosciences, Faculty of Natural Sciences
  • GOEL Harish Chandra
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences

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Tinospora cordifolia (RTc) has already been reported to protect whole-body lethally irradiated mice. This study has focussed on certain aspects of immuno-competence, which are adversely affected by irradiation. This study included estimation of spleen size, cell count, DNA fragmentation and apoptosis in splenocytes. The adherence, spreading and phagocytic activities of macrophages were also assessed. Cytokines in serum and anti-oxidants in plasma were also estimated. Administration of RTc (200 mg/kg.b.wt.) one hour before irradiation showed recovery of spleen weight from 49% of control in irradiated group to 93%; apoptosis from 19% to 2.8%; DNA fragmentation from 43% to 20.4%; macrophage adherence form 75% of control to 120% and macrophage spread size from 8 μm to 15 μm. RTc also stimulated proliferation in splenocytes in a dose-dependent manner. RTc administration before irradiation also increased levels of IL-1β and GM-CSF levels, from 56 pg/ml and 53 pg/ml respectively in irradiated group to 59 pg/ml and 63 pg/ml. Similarly, radiation-induced decrease of anti-oxidant potential of plasma (32 Fe2+ equiv.) as compared to control (132 Fe2+ equiv.) was countered by administration of RTc before irradiation (74.2 Fe2+ equiv.) RTc treatment thus reveals several radio-protective mechanisms.<br>

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