Effects of Crocetin on the Pupillary Response during Accommodation Induced by Visual Display Terminal Work: A Randomized, Double-blind, Placebo-controlled, Crossover Trial

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  • Visual Display Terminal 作業に伴う調節機能低下に対するクロセチン摂取の影響 ―ランダム化二重盲検プラセボ対照クロスオーバー試験―
  • Visual Display Terminal サギョウ ニ トモナウ チョウセツ キノウ テイカ ニ タイスル クロセチン セッシュ ノ エイキョウ : ランダムカ ニジュウ モウケンプラセボ タイショウ クロスオーバー シケン

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The purpose of this study was to examine the effects of crocetin on the pupillary response during accommodation induced by visual display terminal (VDT) work. This clinical study was conducted as a randomized, double-blind, placebo-controlled, crossover trial in healthy adult volunteers with subjective symptoms of eye fatigue. In this study, the pupillary response during accommodation was evaluated using pupil constriction ratio (PCR). PCR was measured before and after VDT work, after rest at baseline, and at each intervention period. Following analysis of variations in PCR, the variation in PCR after rest significantly increased in the crocetin group. According to the visual analog scale questionnaire, subjective symptoms of eye fatigue significantly improved. These results show that ingestion of crocetin for 4 weeks is effective in mitigating the pupillary response during accommodation associated with VDT work.

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