Study on Anti-Proliferative Activities of Cultured <i>Cordyceps Militaris </i>on Cancer Cells

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  • サナギタケ培養液のがん細胞増殖抑制作用に関する研究
  • サナギタケ バイヨウエキ ノ ガン サイボウ ゾウショク ヨクセイ サヨウ ニ カンスル ケンキュウ

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Cordyceps militaris has been known to produce an anticancer agent, cordycepin. Investigation on optimum culture condition for C. militaris had been performed. In the research program for discovering a novel function in the culture of C. militaris, the culture media was applied to a proliferation assays using various cell lines. The media showed significant anti-proliferative activities against al cell lines, especially to human leukemia cell line HL-60. The activity-guided purification of active ingredient was performed to obtain uracil. To the best of our knowledge, uracil has not been reported to possess anti-proliferative activity. However, the uracil obtained from the culture media was subjected to ICP-MS analysis to reveal that sodium, potassium and magnesium were found to co-exist with uracil, which might show anti-proliferative activity. Further study on the mechanism of the expression of the activity is now underway.<br>

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