Mutagenicity Test for Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf  -Reverse Mutation Test, Mouse Lymphoma Assay (MLA) and Mouse Micronucleus Test

HAYASHI Hirotaka, ISHIBASHI Norihito, OHTA Mayumi, ARAI Takanari, SHIGETA Yuko, STRONG Jeffry M, OHTA Tomihisa, SUZUKI Nobutaka

doi:10.1625/jcam.6.157

Mutagenicity Test for Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf -Reverse Mutation Test, Mouse Lymphoma Assay (MLA) and Mouse Micronucleus Test

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HAYASHI Hirotaka

Center for Innovation, Kanazawa University Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
ISHIBASHI Norihito

Biotherapy Development Research Center Co., Ltd.
OHTA Mayumi

Biotherapy Development Research Center Co., Ltd.
ARAI Takanari

Endowed Center for the Advancement of Pregnancy, Perinatal and Infant Care, Kanazawa University Graduate School of Medical Science
SHIGETA Yuko

Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
STRONG Jeffry M

Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
OHTA Tomihisa

Graduate School of Natural Science and Technology, Kanazawa University
SUZUKI Nobutaka

Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University

Bibliographic Information

Other Title

ハトムギ熱水抽出物の変異原性試験　　‐復帰変異試験，マウスリンフォーマ試験　（ＭＬＡ），マウス小核試験‐
ハトムギ熱水抽出物の変異原性試験 : 復帰変異試験, マウスリンフォーマ試験 (MLA), マウス小核試験
ハトムギネッスイチュウシュツブツノヘンイゲンセイシケンフッキヘンイシケンマウスリンフォーマシケン MLA マウスショウカクシケン
—Reverse Mutation Test, Mouse Lymphoma Assay (MLA) and Mouse Micronucleus Test
―復帰変異試験，マウスリンフォーマ試験 (MLA)，マウス小核試験―

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Description

Coix lacryma-jobi L. var. ma-yuen Stapf is a grass long been used in traditional medicine as a nourishing food and reported to possess pharmacological effects including anti-tumor, anti-obesity, anti-diabetic, etc. In order to evaluate the possible mutagenicity of the hot water extract of all parts (husks, pellicles, and astringent skin) of the food, we performed a reverse mutation test in bacteria, a mouse lymphoma assay and a mouse micronucleus test. The results of all tests were negative. It was concluded that the extract has no mutagenicity for living bodies.<br>

Journal

Japanese Journal of Complementary and Alternative Medicine

Japanese Journal of Complementary and Alternative Medicine 6 (3), 157-162, 2009

The Japanese Society for Complementary and Alternative Medicine

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References(7)*help