Clinical utility of FDG-PET in histologic grading and prognostic prediction for patients with salivary gland malignancies

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  • 唾液腺癌の組織学的悪性度診断と予後予測におけるＦＤＧ－ＰＥＴの有用性の検討

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Salivary gland malignancies are unique in their histological and behavioral variability. Decisions on treatment regimens and prognostic prediction require evaluation of the histological diagnoses. Positron emission tomography (PET) using 18F-fluoro-2-deoxy-D-glucose (FDG), which reflects glucose metabolism, has been reported to be useful for the diagnosis of several malignancies. However, the clinical utility of 18F-FDG-PET in evaluating salivary gland malignancies has not been clarified.<br>In this study, we investigated the utility of FDG-PET in histologic grading and prognostic prediction for patients with salivary gland malignancies. To indicate the degree of 18F-FDG accumulation, the standardized uptake value (SUV) was used. High-grade malignancies had significantly higher mean maximum SUVs than did low- and intermediate-grade malignancies. In univariate survival analysis, the cumulative survival decreased as the SUV increased, when the maximum SUV of 7.8 was taken as a cut-off for high and low uptake tumors. We concluded that FDG-PET has a significant impact in histologic grading and prognostic prediction for patients with salivary gland malignancies.

Journal

  • Toukeibu Gan

    Toukeibu Gan 37 (1), 73-77, 2011

    Japan Society for Head and Neck Cancer

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