A comparison of salvage surgery following CRT and following BRT for advanced hypopharyngeal cancer

DOI Web Site 2 Citations
  • Kamijo Tomoyuki
    Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital
  • Onitsuka Tetsuro
    Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital
  • Yokota Tomoya
    Division of Gastrointestinal Oncology, Shizuoka Cancer Center Hospital
  • Ogawa Hirofumi
    Division of Radiation Oncology, Shizuoka Cancer Center Hospital
  • Iida Yoshiyuki
    Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital
  • Nagaoka Masato
    Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital
  • Kitani Takashi
    Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital
  • Hamauchi Satoshi
    Division of Gastrointestinal Oncology, Shizuoka Cancer Center Hospital
  • Onoe Takeshi
    Division of Radiation Oncology, Shizuoka Cancer Center Hospital
  • Nakagawa Masahiro
    Division of Plastic and Reconstructive Surgery, Shizuoka Cancer Center Hospital
  • Inoue Keita
    Division of Plastic and Reconstructive Surgery, Shizuoka Cancer Center Hospital
  • Akazawa Satoshi
    Division of Plastic and Reconstructive Surgery, Shizuoka Cancer Center Hospital
  • Onozawa Yusuke
    Division of Gastrointestinal Oncology, Shizuoka Cancer Center Hospital

Bibliographic Information

Other Title
  • 下咽頭癌CRT/BRT後の救済手術：術式ごとの安全性について

Description

There are still few comparison reports regarding the safety of salvage surgery for recurrence and persistence following platinum-based chemoradiotherapy (CRT) and cetuximab-based bioradiotherapy (BRT), which are frequently used as non-surgical therapies for advanced head and neck carcinomas. This study compared the safety of salvage surgery following CRT against that following BRT for advanced hypopharyngeal cancer. The study examined 34 cases who underwent salvage surgery following CRT and 7 cases who underwent salvage surgery following BRT from September 2002 to December 2015. The number of cases that were able to undergo salvage surgery was 34 among 67 recurrence and persistence cases following CRT and 7 of 8 cases following BRT. In terms of the surgical procedure, salvage neck dissection was conducted for 22 cases in the CRT group and 5 cases in the BRT group, with no significant differences observed between both including the surgical time and amount of bleeding, and with no major complications in either group. Total hypopharynx or total laryngectomy resection for salvage was conducted for 19 cases in the CRT group and 3 cases in the BRT group, upon which we observed anastomotic leakage in 3 cases in the CRT group and 1 case in the BRT group; however, there was no significant difference in the onset frequency.<br>There was no clear difference regarding safety between salvage surgery following CRT and following BRT for locally advanced hypopharyngeal cancer. However, regarding the adaptation of salvage surgery, the possibility of limitations in the CRT group was suggested in comparison with the BRT group.

Journal

  • Toukeibu Gan

    Toukeibu Gan 42 (4), 363-367, 2016

    Japan Society for Head and Neck Cancer

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