Thermodynamic implications of high <i>Q</i><sub>10</sub> of thermoTRP channels in living cells

DOI Web Site PubMed 4 Citations 38 References Open Access
  • Ito Etsuro
    Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
  • Ikemoto Yusuke
    Faculty of Engineering, University of Toyama
  • Yoshioka Tohru
    Graduate Institute of Medicine, School of Medicine, Kaohsiung Medical University

Description

The activity of thermo-transient receptor potential (TRP) channels is highly dependent on temperature, and thus thermo-TRP reactions have a high temperature coefficient Q10. In thermodynamics, a high value of Q10 indicates the existence of a large activation energy (i.e., a large enthalpy) over a short period during the transition process between the closed and open states of the channels. The Gibbs free energy equation shows that a large entropy is required to compensate for this large enthalpy and permit activation of the channels, suggesting a large conformational change of the channels. These large values of enthalpy and entropy seem to be a match for the values of the unfolding process of globular proteins. We outline these thermodynamic issues in thermo-TRPs.

Journal

  • BIOPHYSICS

    BIOPHYSICS 11 (0), 33-38, 2015

    The Biophysical Society of Japan

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