MALIGNANT MELANOMA OF THE SINONASAL MUCOSA: A REVIEW OF 14 CASES

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  • 鼻副鼻腔に発生した悪性黒色腫１４例の臨床的検討

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Malignant melanoma is a rare disease, which accounts for only 1-2% of sinonasal malignant tumors. Attempts have been made to treat if with a combined modality therapy of surgery, radiotherapy, chemotherapy, and immunotherapy, but the prognoses are poor. We reviewed the clinical courses, treatments, and prognoses of 14 cases which received firstline treatment at the Department of the Head and Neck Surgery in Saitama Cancer Center from 1975 to 2003.<BR>All 14 cases received surgery. The surgical procedure was lateral rhinotomy, i.e. resection of the side wall of the nasal cavity, inner wall of the eye socket, nasal turbinates, and mucosa of the sinuses. If the nasal septum was involved, cartilage and/or mucosa were resected together. In addition, radiotherapy, chemotherapy and immunotherapy were also given for each case accordingly.<BR>The 2-year survival rate (Kaplan-Meier method) was 46.2% and the 5-year survival rate was 23.1%. Both the 2-year and 5-year local control rate were 21.4%. The 2-year survival rate of patients whose tumors were totally removed (A) was 42.9%, and not totally removed (B) was 50%. 5-year survival rate of (A) was 50%, however, nobody of (B) could survive for 5 years.<BR>Surgical treatment with lateral rhinotomy seemed to be effective for patients with a small region, especially when limited to one turbinate, however, it was not efficient for patients with a large or septal region. Other treatments are necessary for them, such as skull-base surgery and/or radiotherapy.

Journal

  • Toukeibu Gan

    Toukeibu Gan 31 (4), 511-516, 2005

    Japan Society for Head and Neck Cancer

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