EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR FAMILY IN ORAL SQUAMOUS CELL CARCINOMA CELL LINES AND THEIR RELATIONSHIPS TO LYMPH NODE METASTASIS
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- NAKAZATO Takayuki
- Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences
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- SHINGAKI Susumu
- Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences
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- KITAMURA Nobutaka
- Division of Information Science and Biostatistics, Niigata University Graduate School of Medical and Dental Sciences
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- FUNAYAMA Akinori
- Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences
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- SAITO Chikara
- Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences
Bibliographic Information
- Other Title
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- 口腔へん平上皮がん細胞株におけるVEGF‐familyの発現とリンパ節転移との関連について
Abstract
Angiogenesis and lymphangiogenesis are essential requirements for tumor growth, invasion and metastasis. The vascular endothelial growth factor (VEGF) family, VEGF-A, VEGF-B, VEGF-C and VEGF-D, are thought to be specific potent angio- and lymphangiogenetic stimulators that may play an important role in tumor invasion and metastasis. Although it has been reported that the VEGF family is expressed in a variety of human tumors in different ways, their precise role in oral squamous cell carcinoma (OSCC) is not well understood. To obtain some clues as to this role, we evaluated the expression levels of the VEGF family in OSCC cell lines (HSC-2, HSC-3, HSC-4 and OSC-19) by using quantitative real-time PCR analysis and investigated the relationship with lymph node metastasis, distant metastasis and intratumoral micro vessel density (MVD) in tumor transplanted nude mice. All of the VEGF family were expressed at different levels in four OSCC cell lines. There were significant correlations between VEGF-A, VEGF-C expression and the incidence of lymph node metastasis and the ratio of MVD. These results suggest that VEGF-A and VEGF-C expression may be useful predictors for lymph node metastasis and implicated to treat patients with head and neck SCC for further aggressive therapy.
Journal
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- Toukeibu Gan
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Toukeibu Gan 31 (1), 84-88, 2005
Japan Society for Head and Neck Cancer
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Details 詳細情報について
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- CRID
- 1390282680199840000
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- NII Article ID
- 130004509846
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- ISSN
- 18818382
- 13495747
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed