Altered Expression of Transglutaminase-3 in Chemically-induced Epithelial Dysplasia of Mouse Oral Mucosa

DOI
  • ITO Daisuke
    Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University
  • ISOBE Tomohide
    Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University
  • YOSHIBA Sayaka
    Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University
  • KAWAMATA Ai
    Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University
  • NAGUMO Tatsuhito
    Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University
  • SHINTANI Satoru
    Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University

Bibliographic Information

Other Title
  • 化学誘発性マウスロ腔粘膜上皮性異形成における transglutaminase-3 の発現変化

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Description

Transglutaminases (TG) are widely expressed in variety of tissues and cells and catalyze protein crosslinking reactions. TG-1 and -3 play an important role in the construction of the cornified cell envelop of epithelial cells, and are recently thought to be oncogenes or tumor markers.<br>Here we report an altered expression of TGs during the development of murine experimental dysplasia of the tongue epithelium.<br>Analysis of the gene expression profiles and protein expression revealed a marked upregulation of TG-3 in the experimental dysplasia of wild-type mice. Although similar degree of epithelial dysplasia was induced in p53-deficient mice, TG-3 was not upregulated by the same carcinogen treatment.<br>These data suggested that TG-3 may play a role in the development of murine experimental epithelial dysplasia, and that its function may associate with the p53 tumor suppressor gene.

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Details 詳細情報について

  • CRID
    1390282680199858560
  • NII Article ID
    130003449484
  • DOI
    10.6014/jjomm1995.12.51
  • ISSN
    18841473
    13417983
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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