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The application of theory of altered fractionation on clinics

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  • 多分割照射の基礎と臨床―多分割照射の理論の臨床への応用―

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Altered fractionation schedules are based on two different concepts of radiobiology. One concept is that the radiation repair capability of cells in late responding tissues is higher than that of cells in acute responding tissues which include tumor tissues. Hyperfractionation utilizes this concept. The other concept is that accelerated repopulation of tumor cells occurs in a later period of radiation therapy. In order to overcome repopulation of tumor cells, the technique of accelerated hyperfractionation has been developed. Clinical results of altered fractionation schedules of radiation therapy could be predicted with the linear quadratic model thery for fractionated radiation. However, in the case of concomitant chemotheraoy and altered fractionation, it is difficult to predict its results with a simple radiobiology model. Randomized trias are required to examine the significance of chemoradiotherapy using altered fractionation.


  • Toukeibu Gan

    Toukeibu Gan 33 (3), 280-282, 2007

    Japan Society for Head and Neck Cancer

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