Daily concurrent chemoradiotherapy with docetaxel (DOC) and cisplatin (CDDP) using superselective intra-arterial infusion via superficial temporal artery for advanced oral cancer

DOI 17 Citations 23 References
  • Mitsudo Kenji
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Shigetomi Toshio
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Fukui Takafumi
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Yamamoto Noriyuki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Nishiguchi Hiroaki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Saito Masaki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Nakashima Hideyuki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Usami Kazutada
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Furue Hiroki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Ueda Minoru
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • Tohnai Iwai
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

Bibliographic Information

Other Title
  • 浅側頭動脈よりの超選択的動注法（ＨＦＴ法）を用いた連日同時放射線化学療法―進行口腔癌の原発温存に対する検討―
  • ―進行口腔癌の原発温存に対する検討―

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Abstract

Superselective intra-arterial chemotherapy via superficial temporal artery (HFT method) is feasible for daily concurrent radiotherapy and chemotherapy for oral cancer. The possibility of organ preservation in cases of advanced oral cancer was evaluated. Treatment consisted of superselective intra-arterial infusions (DOC total 60 mg/m2, CDDP total 100 mg/m2) and concurrent radiotherapy (total 40Gy) for four weeks. Patients with T3 and T4 oral cancer were treated with four-week daily concurrent chemoradiotherapy, and the clinical response was evaluated after treatment. Clinical CR of primary sites was obtained in 23 patients, and the same treatment was continued for one or two weeks. Local recurrence was observed in four patients (17.4%), all of whom all patients underwent salvage operation, and the final local control rate was 95.6% (22 of 23 cases). One patient died of neck metastasis, and one died of local recurrence. One-year and 3-year survival rates were estimated by Kaplan-Meier's method to be 95.5% and 79.5%, respectively. In this treatment, it is important to identify the tumor's feeding artery and deliver a sufficient amount of anticancer drug to the tumor. Superselective intra-arterial chemotherapy for oral cancer has the advantage of delivering a high concentration of chemotherapeutic agents into the tumor bed with fewer systemic toxic effects than seen with systemic chemotherapy. Superselective intra-arterial chemotherapy using the HFT method can preserve organs and minimize functional disturbance, thus contributing to patients' QOL.

Journal

  • Toukeibu Gan

    Toukeibu Gan 33 (3), 226-231, 2007

    Japan Society for Head and Neck Cancer

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