Cholesterol and Triglyceride Concentrations in Lipoproteins as Related to Carotid Intima-Media Thickness
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- Takahashi Ryotaro
- Department of Cardiology, Chunichi Hospital
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- Taguchi Noriko
- Department of Cardiology, Chunichi Hospital
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- Suzuki Masayuki
- Department of Cardiology, Chunichi Hospital
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- Cheng Xian Wu
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Numaguchi Yasushi
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Tsukamoto Hideto
- Department of Cardiology, Toki Municipal General Hospital
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- Ikeda Nobuo
- Department of Cardiology, Chunichi Hospital
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Okumura Kenji
- Department of Cardiology, Toki Municipal General Hospital
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説明
Since distinct cholesterol and triglyceride concentrations in major lipoproteins and their subclasses may be related to atherosclerosis, we investigated the relationship of cholesterol and triglyceride concentrations in lipoprotein subclasses and the severity of carotid intima-media thickness (IMT), a surrogate marker of subclinical atherosclerosis. We studied 116 apparently healthy Japanese men (53 ± 9 years) without a history of cardiovascular diseases who were not taking any medication. Carotid IMT was measured by means of high-resolution vascular ultrasound. Plasma cholesterol and triglyceride concentrations in major lipoproteins and their subclasses were determined by HPLC with gel permeation columns. By univariate analyses, carotid IMT was the most closely related to age (r = 0.528, P < 0.001), followed by smoking habit expressed as pack-year cigarette consumption (r = 0.409, P < 0.001). In addition to total cholesterol and LDL cholesterol, carotid IMT was significantly associated with cholesterol and triglyceride concentrations in several LDL and VLDL subclasses. Stepwise multiple linear regression analysis revealed that age (β = 0.436, P < 0.001), smoking (pack-years) (β = 0.225, P = 0.007), and large LDL cholesterol (β = 0.175, P = 0.023) were independent predictors of determining carotid IMT (adjusted R2 = 0.347, P < 0.001). These results indicate that large LDL cholesterol is an important, independent determinant of carotid IMT in healthy men.
収録刊行物
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- International Heart Journal
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International Heart Journal 53 (1), 29-34, 2012
一般社団法人 インターナショナル・ハート・ジャーナル刊行会