Effects of High-frequency Electromagnetic Wave Stimulation on Bone Repair in Rat Calvaria Defects

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  • SATO Takahito
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
  • SUGAYA Tsutomu
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
  • KUDO Megumi
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
  • NAKATANI Mitsunori
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
  • MAEDA Nagako
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
  • KAWANAMI Masamitsu
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
  • TOMINAGA Toshihiko
    Tominaga Dental Clinic, Naruto, Japan

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<p>High-frequency electromagnetic wave stimulation induces proliferation and differentiation of osteoblasts. The aim of the study is to histopathologically evaluate the effects of high-frequency electromagnetic waves on bone formation.</p><p>Bone defects with a diameter of 4.8 mm were created on the left and right sides of the calvarias of Wistar rats. The active electrode was placed in the left defect and high-frequency electromagnetic stimulus was applied for 1 s and repeated five times. This was performed twice a week for 2 weeks. The right defects were not stimulated (control group). After 8 weeks, histological specimens were prepared by hematoxylin and eosin (HE) staining, and the rate of bone formation was measured.</p><p>The rate of bone formation was significantly larger in the experimental group than in the control group. These results indicate that high-frequency electromagnetic wave stimulation enhances bone formation in rat calvarial defects.</p>

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