Study of Pluripotency and Activation of Totipotency in Human Bone Marrow Mesenchymal Stem Cells
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- IZAWA Shunji
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- YAMAJI Kozo
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- HOSHIKA Tomohiro
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- NISHITANI Yoshihiro
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- YOSHIYAMA Masahiro
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Abstract
Tissue regeneration is the important issue in the field of operative dentistry. We demonstrated in series of studies that human bone marrow mesenchymal stem cells (hMSCs) can differentiate into odontblasts under the certain conditions (Izawa S et al., 2009). Mesenchymal stem cells can differentiate into multiple types of cells derived from mesenchyme (Liechty KW et al., 2000). At the same time odontblasts are primarily derived from mesenchyme; thus, we expected that mesenchymal stem cells can differentiate into odontblasts.The results in series of our study indicated that TNFα is necessary for hMSCs to differentiate into odontblasts and suggest that TNFα activates potential totipotency of hMSCs and the activation can lead to the regeneration of target cells or tissues.
Journal
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- Journal of Oral Tissue Engineering
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Journal of Oral Tissue Engineering 10 (2), 95-103, 2012
Japanese Association of Regenerative Dentistry
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Details
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- CRID
- 1390282680201335040
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- NII Article ID
- 130004941084
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- ISSN
- 18800823
- 13489623
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed