Renin-Angiotensin-Aldosterone System Polymorphisms and 5-Year Mortality in Survivors of Acute Myocardial Infarction
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- Hara Masahiko
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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- Sakata Yasuhiko
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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- Nakatani Daisaku
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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- Suna Shinichiro
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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- Usami Masaya
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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- Matsumoto Sen
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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- Sugitani Toshifumi
- Department of Biomedical Statistics, Osaka University Graduate School of Medicine
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- Ozaki Kouichi
- Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences
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- Nishino Masami
- Division of Cardiology, Osaka Rosai Hospital
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- Sato Hiroshi
- School of Human Welfare Studies, Kwansei Gakuin University
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- Kitamura Tetsuhisa
- Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine
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- Nanto Shinsuke
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine
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- Hamasaki Toshimitsu
- Department of Biomedical Statistics, Osaka University Graduate School of Medicine
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- Tanaka Toshihiro
- Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
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- Hori Masatsugu
- Osaka Prefectural Hospital Organization Osaka Medical Center for Cancer and Cardiovascular Diseases
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- Komuro Issei
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine
書誌事項
- タイトル別名
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- A Report From the Osaka Acute Coronary Insufficiency Study
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説明
This study sought to evaluate whether genetic variants in the renin-angiotensin-aldosterone system (RAAS) have an impact on long-term mortality after acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. We investigated the impacts of individual and combinations of 4 major RAAS genetic variants, angiotensinogen (AGT) T1311C, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensin 2 type 1 receptor A1166C, and aldosterone synthase T4660C on 5-year mortality in 3149 post-AMI patients using multivariate Cox regression analysis. The predictive accuracy of all possible RAAS genetic combinations was evaluated using Cox regression analysis, and the best combination that affected prognosis was determined based on the minimal Akaike Information Criterion. There were 220 deaths during a median follow-up of 4.9 years. Independent analyses of any single RAAS variant did not show signifi cant impacts on 5-year mortality. However, analyses in combination revealed that absence of both AGT CC genotype and ACE D allele was associated with lower 5-year mortality (log-rank P = 0.005). Patients with at least either of the AGT CC or ACE D allele had increased mortality with adjusted hazard ratios of 2.07 (95% confi dence interval 1.18-3.65, P = 0.012), compared with those with neither the AGT CC nor ACE D allele. Among the 4 RAAS genetic variants examined, a combination of AGT and ACE polymorphisms was associated with 5-year mortality after AMI.
収録刊行物
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- International Heart Journal
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International Heart Journal 55 (3), 190-196, 2014
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282680201560960
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- NII論文ID
- 130004449392
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- NII書誌ID
- AA12013242
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- COI
- 1:CAS:528:DC%2BC2cXhtFGrt7jP
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- ISSN
- 13493299
- 13492365
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- PubMed
- 24806378
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可