Effects of BMP-2 Injected into the Palatal Sites on Bone Formation
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- YAMAJI Kozo
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- TAKAHASHI Kei
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- NISHITANI Yoshihiro
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- IZAWA Shunji
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- HORIKAWA Gen
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- NISHIMURA Maiko
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- HOSHIKA Tomohiro
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- YOSHIYAMA Masahiro
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Abstract
This study was designed to evaluate the effects of recombinant human BMP-2 (rhBMP-2) injected into the palatal periosteal sites in Wister rats on bone formation. The implant sites were separately divided into four groups according to the dosage of rhBMP-2 : 0 µg, 0.1 µg, 0.5 µg and 1.0 µg. The rats were sacrificed at 3 weeks after implantation, followed by histopathologic observation and histometric evaluation of new bone. Implants had disappeared at every group and new bone formation was observed at 0.1 µg, 0.5 µg and 1.0 µg. New bone was continuous with the original bone at 0.5 µg and 1.0 µg. Thickness of new bone increased as the dosage increased from 0 µg to 0.5 µg (P<0.05), and did not significantly change as the dosage increased from 0.5 µg to 1.0 µg. These results suggested that rhBMP-2 injected into the palatal periosteal sites could lead to induce new bone formation, although its effects varied according to the dosage of rhBMP-2.
Journal
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- Journal of Oral Tissue Engineering
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Journal of Oral Tissue Engineering 6 (1), 62-66, 2008
Japanese Association of Regenerative Dentistry
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Details
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- CRID
- 1390282680201636992
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- NII Article ID
- 110007004840
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- NII Book ID
- AA1195240X
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- ISSN
- 18800823
- 13489623
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed