Cognitive function in Parkinson’s disease and restless legs syndrome

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  • Miyamoto Masayuki
    School of Nursing, Dokkyo Medical University Department of Neurology, Dokkyo Medical University School of Medicine

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  • パーキンソン病／レストレスレッグス症候群の認知機能
  • イブニングセミナー パーキンソン病/レストレスレッグス症候群の認知機能
  • イブニングセミナー パーキンソンビョウ/レストレスレッグス ショウコウグン ノ ニンチ キノウ

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Abstract

<p>Parkinson’s disease （PD）, a progressive neurodegenerative disease, has been traditionally defined by its characteristic motor symptoms.　Cognitive impairment is one of the most common and important non-motor symptoms of PD that, greatly affects functioning and quality of life.　Cognitive decline in PD is characterized by its heterogeneity, with impairments manifesting in one or multiple cognitive domains.　Most PD patients eventually develop impairment of attentional, executive, and visuospatial function.　Dopaminergic deficits in the frontostriatal circuits cause mainly executive, cognitive deficits.　By contrast, cholinergic depletion has a cognitive profile of memory and visuoconstructional deficits.</p><p>Restless legs syndrome （RLS） is a sleep-related movement disorder with disturbed sleep and reduced quality of life.　Specific neurocognitive domains including executive attention, working memory, and divergent higher cognitive functions are particularly vulnerable to sleep loss.　The sleep deprivation associated with RLS also results in neurocognitive performance decrements similar to those seen in sleep restriction studies;, however, the reported impact of RLS on cognition has been conflicting.</p><p>In this review, cognitive functions in PD and RLS is discussed.</p>

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