家兎を用いた椎体間固定用チタン性ケージのporous type, non-porous type間での組織学的・力学的検討

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  • Histological and Mechanical Analysis of Porous Type Cage and Non-Porous Type Cage of Titanium; An Experimental Study in the Rabbit Tibia

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Background: Recently, there has been a rapid increase in the use of titanium cervical spine interbody fusion cages as an adjunct to anterior cervical decompression and fusion. There are few reports about the histological and mechanical properties of the titanium cages. The purpose of the present study is to evaluate the histological analysis and removal torque of porous micro-cages (PC) and non-porous micro-cages (NPC) and compare them.<br>Methods and Results: The PC and NPC were inserted in the tibia of rabbits. The tibiae containing the implants were harvested at 4, 8, and 12 weeks after implantation and histological, microradiographical and mechanical evaluations were performed. Histologic examination by Hematoxylin-Eosin staining and contact microradiography (CMR) revealed that a direct bone-to-implant contact was found during early post-implantation in PC groups, whereas soft tissue was observed on the surface of NPCs even 12 weeks after implantation. After a healing time of 4, 8, and 12 weeks the average removal torques were 0.091±0.03, 0.096±0.055, and 0.156±0.05Nm for NPC groups, 0.129±0.068, 0.217±0.118, and 0.423±0.093Nm for PC groups. In PC groups, there was a gradual increase of removal torque value with the increasing time of follow-up. The difference between NPC and PC groups was not significant at 4 weeks but was significant at 8 weeks (P<0.003) and 12 weeks (P<0.0001) after implantation.<br>Conclusion: The PC groups achieved higher removal torque values compared to the NPC group, and these values might be related with the higher bone-to-implant contact. Therefore, PC might have higher fixation than NPC from early stages.

収録刊行物

  • 脊髄外科

    脊髄外科 19 (1), 19-27, 2005

    日本脊髄外科学会

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